lamon-micrornasinskeletal-2013.pdf (932.1 kB)
MicroRNAs in skeletal muscle and their regulation with exercise, ageing, and disease
journal contribution
posted on 2013-01-01, 00:00 authored by Evelyn Zacharewicz, Severine LamonSeverine Lamon, Aaron RussellAaron RussellSkeletal muscle makes up approximately 40% of the total body mass, providing structural support and enabling the body to maintain posture, to control motor movements and to store energy. It therefore plays a vital role in whole body metabolism. Skeletal muscle displays remarkable plasticity and is able to alter its size, structure and function in response to various stimuli; an essential quality for healthy living across the lifespan. Exercise is an important stimulator of extracellular and intracellular stress signals that promote positive adaptations in skeletal muscle. These adaptations are controlled by changes in gene transcription and protein translation, with many of these molecules identified as potential therapeutic targets to pharmacologically improve muscle quality in patient groups too ill to exercise. MicroRNAs (miRNAs) are recently identified regulators of numerous gene networks and pathways and mainly exert their effect by binding to their target messenger RNAs (mRNAs), resulting in mRNA degradation or preventing protein translation. The role of exercise as a regulatory stimulus of skeletal muscle miRNAs is now starting to be investigated. This review highlights our current understanding of the regulation of skeletal muscle miRNAs with exercise and disease as well as how they may control skeletal muscle health.
History
Journal
Frontiers in physiologyVolume
4Article number
266Pagination
1 - 11Publisher
FrontiersLocation
Lausanne, SwitzerlandPublisher DOI
eISSN
1664-042XLanguage
engPublication classification
C1.1 Refereed article in a scholarly journalCopyright notice
2013, FrontiersUsage metrics
Keywords
ageingdiseaseexercisemiRNAskeletal muscleScience & TechnologyLife Sciences & BiomedicinePhysiologyDUCHENNE MUSCULAR-DYSTROPHYSERUM RESPONSE FACTORRESISTANCE EXERCISEPROTEIN-SYNTHESISENDURANCE EXERCISECIRCULATING MICRORNASCELL-PROLIFERATIONMESSENGER-RNATRANSCRIPTION FACTORSMOLECULAR REGULATIONPhysiology
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