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Microbiome-focused asthma management strategies

Version 2 2024-06-05, 04:24
Version 1 2021-09-22, 08:16
journal contribution
posted on 2024-06-05, 04:24 authored by SD Shukla, MD Shastri, WC Chong, K Dua, KF Budden, Malik Quasir MahmoodMalik Quasir Mahmood, NG Hansbro, S Keely, R Eri, RP Patel, GM Peterson, PM Hansbro
Asthma is a common, heterogeneous and serious disease with high prevalence globally. Poorly controlled, steroid-resistant asthma is particularly important as there are no effective therapies and it exerts substantial healthcare and societal burden. The role of microbiomes, particularly in chronic diseases has generated considerable interest in recent times. Existing evidence clearly demonstrates an association between asthma initiation and the microbiome, both respiratory and gastro-intestinal, although its’ roles are poorly understood when assessing the asthma progression or heterogeneity (i.e. phenotypes/endotypes) across different geographical locations. Moreover, modulating microbiomes could be preventive and/or therapeutic in patients with asthma warrants urgent attention. Here, we review recent advances in assessing the role of microbiomes in asthma and present the challenges associated with the potential therapeutic utility of modifying microbiomes in management.

History

Journal

Current Opinion in Pharmacology

Volume

46

Pagination

143-149

Location

Amsterdam, The Netherlands

ISSN

1471-4892

eISSN

1471-4973

Language

eng

Publication classification

C1 Refereed article in a scholarly journal

Publisher

Elsevier

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