File(s) under permanent embargo
Microencapsulation of coupled folate and chitosan nanoparticles for targeted delivery of combination drugs to colon
journal contribution
posted on 2015-01-01, 00:00 authored by P Li, Z Yang, Yichao Wang, Z Peng, S Li, Lingxue KongLingxue Kong, Yichao WangFolate-chitosan nanoparticles, co-loaded with 5-fluourouacil (5-FU) and leucovorin (LV) and prepared by ionic gelation technology were physically microencapsulated by enteric polymer using a solvent evaporation method. Average particle size of the microencapsulated particles was in the range of 15 to 35 µm. High drug encapsulation efficiency was obtained for both 5-FU and LV in the microencapsulated particles. Both drugs were in amorphous state in the microencapsulated particles. By enteric coating, excellent pH-dependent release profile was achieved and no drug release was observed in simulated gastric and intestinal fluids. However, when the pH value reached the soluble threshold of Eudragit S-100, a constant and slow drug release was observed. The results indicated that these microencapsulated particles are a promising vehicle for selectively targeting drugs to colon in the chemotherapy of colon cancer.
History
Journal
Journal of microencapsulationVolume
32Issue
1Pagination
40 - 45Publisher
Taylor and FrancisLocation
London, EngPublisher DOI
ISSN
1464-5246eISSN
1464-5246Language
engPublication classification
C Journal article; C1 Refereed article in a scholarly journalCopyright notice
2015, Taylor and FrancisUsage metrics
Categories
No categories selectedKeywords
5-Fluorouricalcolon cancerdrug deliveryleucovorinmicroencapsulationCapsulesChitosanColonColonic NeoplasmsDrug CarriersFolic AcidHumansNanoparticlesPolymethacrylic AcidsScience & TechnologyPhysical SciencesTechnologyLife Sciences & BiomedicineChemistry, AppliedEngineering, ChemicalPharmacology & PharmacyChemistryEngineeringMULTIPARTICULATE SYSTEMIN-VITROGUAR GUMDESIGNMICROSPHERES5-FLUOROURACILPOLYSACCHARIDES
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC