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Midsagittal corpus callosum area and conversion to multiple sclerosis after clinically isolated syndrome: a multicentre Australian cohort study
journal contribution
posted on 2017-08-01, 00:00 authored by C Odenthal, S Simpson, J Oughton, I van der Mei, S Rose, J Fripp, R Lucas, B Taylor, K Dear, A-L Ponsonby, A Coulthard, Ausimmune AusLong Investigator Groups, Cameron ShawCameron ShawINTRODUCTION: Patients presenting with clinically isolated syndrome (CIS) may proceed to clinically definite multiple sclerosis (CDMS). Midsagittal corpus callosum area (CCA) is a surrogate marker for callosal atrophy, and can be obtained from a standard MRI study. This study explores the relationship between CCA measured at CIS presentation (baseline) and at 5 years post presentation, with conversion from CIS to CDMS. The association between CCA and markers of disability progression is explored. METHODS: Corpus callosum area was measured on MRI scans at presentation and 5-year review following diagnosis of a first demyelinating event, or evidence of progressive MS, in 143 participants in the Ausimmune/AusLong Study. Relationships between CCA (at baseline and follow-up) and clinical outcomes were assessed. RESULTS: Mean CCA at baseline study was 6.63 cm2 (SD 1.01). Patients who converted to MS by 5-year review (n = 100) had a significantly smaller mean CCA at follow-up (6.22 vs. 6.74, P = 0.007). Greater CCA reduction was associated with higher annualized relapse rate over follow-up. CONCLUSION: Baseline CCA obtained from standard MRI protocols may be compared with subsequent MRI examinations as a surrogate for neurodegeneration and cerebral atrophy in patients with MS. This study demonstrates an association between CCA and disability in individuals presenting with CIS who convert to MS.
History
Journal
Journal of medical imaging and radiation oncologyVolume
61Issue
4Pagination
453 - 460Publisher
John Wiley & SonsLocation
Chichester, Eng.Publisher DOI
eISSN
1754-9485Language
engPublication classification
C Journal article; C1 Refereed article in a scholarly journalCopyright notice
2016, The Royal Australian and New Zealand College of RadiologistsUsage metrics
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