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Minocycline as Treatment for Psychiatric and Neurological Conditions: A Systematic Review and Meta-Analysis
journal contribution
posted on 2023-04-14, 03:58 authored by B Panizzutti, David SkvarcDavid Skvarc, S Lin, S Croce, A Meehan, Chiara BortolasciChiara Bortolasci, Wolf MarxWolf Marx, Adam WalkerAdam Walker, K Hasebe, Bianca KavanaghBianca Kavanagh, MJ Morris, Mohammadreza MohebbiMohammadreza Mohebbi, Alyna TurnerAlyna Turner, Laura GrayLaura Gray, Lesley BerkLesley Berk, Ken WalderKen Walder, M Berk, Olivia DeanOlivia DeanMinocycline has anti-inflammatory, antioxidant, and anti-apoptotic properties that explain the renewed interest in its use as an adjunctive treatment for psychiatric and neurological conditions. Following the completion of several new clinical trials using minocycline, we proposed an up-to-date systematic review and meta-analysis of the data available. The PICO (patient/population, intervention, comparison and outcomes) framework was used to search 5 databases aiming to identify randomized controlled trials that used minocycline as an adjunctive treatment for psychiatric and neurological conditions. Search results, data extraction, and risk of bias were performed by two independent authors for each publication. Quantitative meta-analysis was performed using RevMan software. Literature search and review resulted in 32 studies being included in this review: 10 in schizophrenia, 3 studies in depression, and 7 in stroke, with the benefit of minocycline being used in some of the core symptoms evaluated; 2 in bipolar disorder and 2 in substance use, without demonstrating a benefit for using minocycline; 1 in obsessive-compulsive disorder, 2 in brain and spinal injuries, 2 in amyotrophic lateral sclerosis, 1 in Alzheimer's disease, 1 in multiple systems atrophy, and 1 in pain, with mixes results. For most of the conditions included in this review the data is still limited and difficult to interpret, warranting more well-designed and powered studies. On the other hand, the studies available for schizophrenia seem to suggest an overall benefit favoring the use of minocycline as an adjunctive treatment.
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Journal
International journal of molecular sciencesVolume
24Article number
5250Pagination
5250-5250Location
SwitzerlandPublisher DOI
ISSN
1422-0067eISSN
1422-0067Language
enIssue
6Publisher
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Keywords
adjunctive treatmentmeta-analysisminocyclineneurologypsychiatryHumansMinocyclineSchizophreniaBipolar DisorderObsessive-Compulsive DisorderAnti-Inflammatory AgentsClinical ResearchSerious Mental IllnessBrain DisordersClinical Trials and Supportive ActivitiesMental HealthNeurosciencesMental healthNeurological3 Good Health and Well BeingChemical Sciences not elsewhere classifiedGeneticsBiological Sciences not elsewhere classified
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