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Mitochondrial dysfunction in the pathophysiology of bipolar disorder: effects of pharmacotherapy
journal contribution
posted on 2015-01-01, 00:00 authored by E Callaly, Ken WalderKen Walder, G Morris, M. Maes, M Debnath, Michael BerkMichael BerkBipolar disorder is a common, chronic, and complex mental illness. Bipolar disorder is frequently comorbid with primary mitochondrial and metabolic disorders, and studies have implicated mitochondrial dysfunction in its pathophysiology. In the brains of people with bipolar disorder, high-energy phosphates are decreased, lactate is elevated and pH decreased, which together suggest a shift toward glycolysis for energy production. Furthermore, oxidative stress is increased, and calcium signalling dysregulated. Additionally there is downregulation of the expression of mitochondrial complexes, especially complex I. The therapeutic effects of some bipolar disorder drugs have recently been shown to be related to these mechanisms. In this review we will evaluate current research on the interactions between mitochondrial dysfunction and bipolar disorder pathology. We will then appraise the current literature describing the effects of bipolar disorder drugs on mitochondrial function, and discuss ramifications for future research.
History
Journal
Mini-reviews in medicinal chemistryVolume
15Issue
5Pagination
355 - 365Publisher
Bentham Science PublishersLocation
Amsterdam, The NetherlandseISSN
1875-5607Language
engPublication classification
C Journal article; C1 Refereed article in a scholarly journalCopyright notice
2015, Bentham Science PublishersUsage metrics
Categories
Keywords
Bipolar disorderMitochondriaMood stabiliserNeuroprogressionOxidative stressScience & TechnologyLife Sciences & BiomedicineChemistry, MedicinalPharmacology & PharmacyTUMOR-NECROSIS-FACTORELECTRON-TRANSPORT CHAINANTERIOR CINGULATE CORTEXCENTRAL-NERVOUS-SYSTEMMAGNETIC-RESONANCE-SPECTROSCOPYPLACEBO-CONTROLLED TRIALSUBUNIT GENE NDUFV2FACTOR-ALPHANITRIC-OXIDE