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Models for loosely linked gene duplicates suggest lengthy persistence of both copies
journal contributionposted on 2007-06-21, 00:00 authored by Martin O'HelyMartin O'Hely, L Wockner
Consider the appearance of a duplicate copy of a gene at a locus linked loosely, if at all, to the locus at which the gene is usually found. If all copies of the gene are subject to non-functionalizing mutations, then two fates are possible: loss of functional copies at the duplicate locus (loss of duplicate expression), or loss of functional copies at the original locus (map change). This paper proposes a simple model to address the probability of map change, the time taken for a map change and/or loss of duplicate expression, and considers where in the spectrum between loss of duplicate expression and map change such a duplicate complex is likely to be found. The findings are: the probability of map change is always half the reciprocal of the population size N, the time for a map change to occur is order NlogN generations, and that there is a marked tendency for duplicates to remain near equi-frequency with the gene at the original locus for a large portion of that time. This is in excellent agreement with simulations.
JournalJournal of theoretical biology
Pagination636 - 645
LocationAmsterdam, The Netherlands
Publication classificationC1.1 Refereed article in a scholarly journal
Copyright notice2007, Elsevier Ltd.
Chromosome MappingGene DuplicationGene FrequencyGenes, DuplicateHumansMathematicsModels, GeneticMutationProbabilityTime FactorsScience & TechnologyLife Sciences & BiomedicineBiologyMathematical & Computational BiologyLife Sciences & Biomedicine - Other Topicsmap changeddiffusion modelascertainment2 TIME SCALESDIFFUSION APPROXIMATIONSPOPULATION-GENETICSTETRAPLOID FISHMARKOV-CHAINSLOCIPOLYMORPHISM