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Molecular imaging of metabolism in cancer metastasis

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Version 2 2024-06-17, 11:32
Version 1 2015-03-19, 16:09
journal contribution
posted on 2024-06-17, 11:32 authored by N Pouliot, D Denoyer
Cancer progression is characterised by extensive metabolic reprogramming. Renewed enthusiasm in this field has been sparked in part by the realisation that metabolic pathways, oncogenes and tumour suppressors are intimately linked and regulate tumour growth and metastasis through complex reciprocal interactions. The identification of key pathways and enzymes regulating metabolism in cancer cells provides new opportunities for cancer therapy. This has motivated the development of several specific inhibitors targeting metabolic pathways and their therapeutic evaluation in pre-clinical models or in cancer patients. The unravelling of metabolic pathways associated with cancer progression has also highlighted the extensive metabolic heterogeneity that exists between, and within, each cancer type as well as between metastatic sites. The translation of these findings into personalised therapy remains a considerable challenge. To this end, the use of positron emission tomography to non-invasively visualise tumour metabolism is likely to facilitate the implementation of and assessment of new targeted therapies. Here, we briefly review the key metabolic changes associated with cancer progression and discuss recent advances in the field of positron emission tomography for metabolic imaging of cancer and their potential to improve the clinical management of cancer patients.

History

Journal

Cancer Forum

Volume

38

Pagination

124-128

Location

Kogarah, N.S.W.

Open access

  • Yes

ISSN

0311-306X

Language

English

Publication classification

C Journal article, C1 Refereed article in a scholarly journal

Copyright notice

2014, Cancer Council Australia

Issue

2

Publisher

AUSTRALIAN CANCER SOC INC