Deakin University
Browse
tran-molecularinteractions-2020.pdf (907.83 kB)

Molecular interactions in solid dispersions of poorly water-soluble drugs

Download (907.83 kB)
journal contribution
posted on 2020-08-07, 00:00 authored by T T D Tran, Phuong TranPhuong Tran
Physicochemical characterization is a crucial step for the successful development of solid dispersions, including the determination of drug crystallinity and molecular interactions. Typically, the detection of molecular interactions will assist in the explanation of different drug performances (e.g., dissolution, solubility, stability) in solid dispersions. Various prominent reviews on solid dispersions have been reported recently. However, there is still no overview of recent techniques for evaluating the molecular interactions that occur within solid dispersions of poorly water-soluble drugs. In this review, we aim to overview common methods that have been used for solid dispersions to identify different bond formations and forces via the determination of interaction energy. In addition, a brief background on the important role of molecular interactions will also be described. The summary and discussion of methods used in the determination of molecular interactions will contribute to further developments in solid dispersions, especially for quick and potent drug delivery applications.

History

Journal

Pharmaceutics

Volume

12

Issue

8

Pagination

1 - 12

Publisher

MDPI AG

Location

Basel, Switzerland

ISSN

1999-4923

eISSN

1999-4923

Language

eng

Publication classification

C1 Refereed article in a scholarly journal

Usage metrics

    Research Publications

    Categories

    No categories selected

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC