Deakin University
Browse

File(s) under embargo

Mood disorders: the gut bacteriome and beyond

journal contribution
posted on 2023-10-02, 23:58 authored by Amelia McGuinnessAmelia McGuinness, Amy Loughman, Jane A Foster, Felice JackaFelice Jacka
Knowledge of the microbiome-gut-brain axis has revolutionized the field of psychiatry. It is now well recognized that the gut bacteriome is associated with, and likely influences, the pathogenesis of mental disorders, including major depressive disorder and bipolar disorder. However, whilst substantial advances in the field of microbiome science have been made, we have likely only scratched the surface in our understanding of how these ecosystems might contribute to mental disorder pathophysiology. Beyond the gut bacteriome, research into lesser explored components of the gut microbiome, including the gut virome, mycobiome, archaeome, and parasitome, is increasingly suggesting relevance in psychiatry. The contribution of microbiomes beyond the gut, including the oral, lung, and small intestinal microbiomes, to human health and pathology should not be overlooked. Increasing both our awareness and understanding of these less traversed fields of research is critical to improving the therapeutic benefits of treatments targeting the gut microbiome, including fecal microbiome transplantation, postbiotics and biogenics, and dietary intervention. Interdisciplinary collaborations integrating systems biology approaches are required to fully elucidate how these different microbial components and distinct microbial niches interact with each other and their human hosts. Excitingly, we may be at the start of the next microbiome revolution, and thus one step closer to informing the field of precision psychiatry to improve outcomes for those living with mental illness.

History

Journal

Biological Psychiatry

Pagination

1-32

Location

Amsterdam, The Netherlands

ISSN

0006-3223

eISSN

1873-2402

Language

eng

Publication classification

C1 Refereed article in a scholarly journal

Publisher

Elsevier