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Multidrug Resistance in Cancer: Understanding Molecular Mechanisms, Immunoprevention and Therapeutic Approaches

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journal contribution
posted on 2022-11-10, 00:59 authored by TB Emran, A Shahriar, AR Mahmud, T Rahman, MH Abir, MFR Siddiquee, H Ahmed, N Rahman, F Nainu, E Wahyudin, S Mitra, K Dhama, MM Habiballah, S Haque, Ariful IslamAriful Islam, MM Hassan
Cancer is one of the leading causes of death worldwide. Several treatments are available for cancer treatment, but many treatment methods are ineffective against multidrug-resistant cancer. Multidrug resistance (MDR) represents a major obstacle to effective therapeutic interventions against cancer. This review describes the known MDR mechanisms in cancer cells and discusses ongoing laboratory approaches and novel therapeutic strategies that aim to inhibit, circumvent, or reverse MDR development in various cancer types. In this review, we discuss both intrinsic and acquired drug resistance, in addition to highlighting hypoxia- and autophagy-mediated drug resistance mechanisms. Several factors, including individual genetic differences, such as mutations, altered epigenetics, enhanced drug efflux, cell death inhibition, and various other molecular and cellular mechanisms, are responsible for the development of resistance against anticancer agents. Drug resistance can also depend on cellular autophagic and hypoxic status. The expression of drug-resistant genes and the regulatory mechanisms that determine drug resistance are also discussed. Methods to circumvent MDR, including immunoprevention, the use of microparticles and nanomedicine might result in better strategies for fighting cancer

History

Journal

Frontiers in Oncology

Volume

12

Article number

891652

Pagination

1-38

Location

Lausanne, Switzerland

Open access

  • Yes

ISSN

2234-943X

eISSN

2234-943X

Language

eng

Publication classification

C1.1 Refereed article in a scholarly journal

Publisher

Frontiers Media