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Multifunctional and multitargeted nanoparticles for drug delivery to overcome barriers of drug resistance in human cancers

journal contribution
posted on 2013-12-01, 00:00 authored by Swati Dawar, Neha Singh, Rupinder Kanwar, Lee KennedyLee Kennedy, R Veedu, S Zhou, S Krishnakumar, S Hazra, S Sasidharan, Wei DuanWei Duan, Jagat Kanwar
The recurrence and metastatic spread of cancer are major drawbacks in cancer treatment. Although chemotherapy is one of the most effective methods for the treatment of metastatic cancers, it is nonspecific and causes significant toxic damage. The development of drug resistance to chemotherapeutic agents through various mechanisms also limits their therapeutic potential. However, as we discuss here, the use of nanodelivery systems that are a combination of diagnostics and therapeutics (theranostics) is as relatively novel concept in the treatment of cancer. Such systems are likely to improve the therapeutic benefits of encapsulated drugs and can transit to the desired site, maintaining their pharmaceutical properties. The specific targeting of malignant cells using multifunctional nanoparticles exploits theranostics as an improved agent for delivering anticancer drugs and as a new solution for overriding drug resistance.

History

Journal

Drug discovery today

Volume

18

Issue

23-24

Pagination

1292 - 1300

Publisher

Elsevier

Location

London, England

ISSN

1359-6446

eISSN

1878-5832

Language

eng

Publication classification

C1 Refereed article in a scholarly journal

Copyright notice

2013, Elsevier