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Multifunctional, biocompatible and pH-responsive carbon nanotube- and graphene oxide/tectomer hybrid composites and coatings

Version 2 2024-06-03, 23:24
Version 1 2017-02-22, 22:52
journal contribution
posted on 2024-06-03, 23:24 authored by R Garriga, I Jurewicz, S Seyedin, N Bardi, S Totti, B Matta-Domjan, EG Velliou, MA Alkhorayef, VL Cebolla, Joselito RazalJoselito Razal, AB Dalton, E Muñoz
Here we present a route for non-covalent functionalization of carboxylated multi-walled carbon nanotubes and graphene oxide with novel two-dimensional peptide assemblies. We show that self-assembled amino-terminated biantennary and tetraantennary oligoglycine peptides (referred to as tectomers) effectively coat carboxylated multi-walled carbon nanotubes and also strongly interact with graphene oxide due to electrostatic interactions and hydrogen bonding as the driving force, respectively. The resulting hybrids can be made into free-standing conducting composites or applied in the form of thin, pH-switchable bioadhesive coatings onto graphene oxide fibers. Monitoring of cell viability of pancreatic cell lines, seeded on those CNT hybrids, show that they can be used as two- and three-dimensional scaffolds to tissue engineer tumour models for studying ex vivo the tumour development and response to treatment. This highly versatile method in producing pH-responsive hybrids and coatings offers an attractive platform for a variety of biomedical applications and for the development of functional materials such as smart textiles, sensors and bioelectronic devices.

History

Journal

Nanoscale

Volume

9

Pagination

7791-7804

Location

England

ISSN

2040-3364

eISSN

2040-3372

Language

English

Publication classification

C Journal article, C1 Refereed article in a scholarly journal

Copyright notice

2017, The Royal Society of Chemistry

Issue

23

Publisher

ROYAL SOC CHEMISTRY