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Multiple scan averaging to yield accurate quantitative analysis of optical coherence tomography angiograms

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Version 2 2024-06-05, 01:44
Version 1 2020-04-16, 08:43
journal contribution
posted on 2024-06-18, 20:22 authored by HM Khan, Alex GentleAlex Gentle, James ArmitageJames Armitage, CH To, AKC Lam
AbstractOptical coherence tomography angiography (OCTA) is widely used in ophthalmic practice. Most OCTA studies based their findings on a single OCTA measurement. We conducted an observational study of 82 eyes from 82 healthy subjects to compare variations of OCTA parameters among five successive measurements. A 3 × 3 mm Early Treatment of Diabetic Retinopathy Study grid centred at fovea was used. An average from five successive OCTA measurements (both perfusion density and vessel density) was calculated to be used as the reference standard. There was no significant difference in perfusion and vessel densities among five successive OCTA measurements, and from different levels of averaging. Perfusion density was close to the reference standard when average from three measurements was used (discrepancy within 1.5%) as compared with using just one measurement (discrepancy from 3.2% to 4.5%). Vessel density was also close to reference standard when average from three measurements was used (within 0.8 mm−1) as compared with using just one measurement (2 mm−1). Software feature that allows OCTA devices to average quantitative parameters for analysis will be useful.

History

Journal

Scientific Reports

Volume

10

Article number

ARTN 6194

Location

England

Open access

  • Yes

ISSN

2045-2322

eISSN

2045-2322

Language

English

Publication classification

C1 Refereed article in a scholarly journal

Copyright notice

2020, The Authors

Issue

1

Publisher

NATURE RESEARCH