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Multiplexed dual second-dimension column comprehensive two-dimensional gas chromatography (GC × 2GC) using thermal modulation and contra-directional second-dimension columns

journal contribution
posted on 2013-11-25, 00:00 authored by Benjamin Savareear, Robert Shellie
A multiplexed dual-secondary column comprehensive two-dimensional gas chromatography approach (GC×2GC) designed for complex sample analysis is introduced. The approach splits the first-dimension column effluent into two second-dimension columns with different stationary phases, and recombines the two streams into one detector post-separation. The approach produces two single two-dimensional chromatograms for each injection. Careful manipulation of thermal modulator timing parameters combined with a novel contra-directional modulation regime facilitates this approach. A selection of 34 laboratory reference compounds containing n-alkanes, alcohols, aromatic hydrocarbons, ketones, esters and halogenated hydrocarbons were analysed to demonstrate the approach. The dual two-dimensional chromatogram from this single detector system provides complementary information due to the unique selectivity of the three separation columns. The results of this proof-of-principle investigation provide significant impetus for further development of GC×2GC-MS methodology.

History

Journal

Analytica Chimica Acta

Volume

803

Pagination

160 - 165

Publisher

Elsevier

Location

Amsterdam, The Netherlands

ISSN

0003-2670

eISSN

1873-4324

Language

eng

Publication classification

C1 Refereed article in a scholarly journal

Copyright notice

2013, Elsevier