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Muscle glycogen and metabolic regulation

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journal contribution
posted on 2004-05-01, 00:00 authored by Mark Hargreaves
Muscle glycogen is an important fuel for contracting skeletal muscle during prolonged strenuous exercise, and glycogen depletion has been implicated in muscle fatigue. It is also apparent that glycogen availability can exert important effects on a range of metabolic and cellular processes. These processes include carbohydrate, fat and protein metabolism during exercise, post-exercise glycogen resynthesis, excitation–contraction coupling, insulin action and gene transcription. For example, low muscle glycogen is associated with reduced muscle glycogenolysis, increased glucose and NEFA uptake and protein degradation, accelerated glycogen resynthesis, impaired excitation–contraction coupling, enhanced insulin action and potentiation of the exercise-induced increases in transcription of metabolic genes. Future studies should identify the mechanisms underlying, and the functional importance of, the association between glycogen availability and these processes.

History

Journal

The proceedings of the nutrition society

Volume

63

Pagination

217 - 220

Location

Cambridge, England

Open access

  • Yes

ISSN

0029-6651

eISSN

1475-2719

Language

eng

Publication classification

C1 Refereed article in a scholarly journal

Copyright notice

2004, The Author

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