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Mushroom lectins as promising anticancer substances

Version 2 2024-06-13, 10:19
Version 1 2017-04-05, 10:43
journal contribution
posted on 2024-06-13, 10:19 authored by RS Singh, HP Kaur, JR Kanwar
Lectins are proteins/glycoproteins of non-immune origin, which are widely distributed in nature. They have at least one non-catalytic domain, which binds reversibly to specific monosaccharides or oligosaccharides. Lectins recognizing sugar moieties in cell walls or cell membranes alter the membrane physiology and trigger biochemical changes in the cell. Thus, various applications of lectins have been described, for example as tools to identify aberrant glycans expressed by neoplastic cells and as antitumor agents by inducing apoptosis by various mechanisms. In order to widen applications of anti-tumor lectins, a detailed investigation of their action mechanism is required. Mushrooms are a valuable source of novel lectins with unique specificities and potentials for biotechnological and biomedical applications. This article reviews information on anti-proliferative activity of mushroom lectins obtained in-vitro and in-vivo. The possible role of lectins as cancer therapeutics is discussed together with the mechanisms underlying the anti-proliferative activity, which may help to exploit these biomolecules as potential novel antitumor drugs in near future.

History

Journal

Current protein & peptide science

Volume

17

Pagination

797-807

Location

Beijing, China

ISSN

1389-2037

eISSN

1875-5550

Language

eng

Publication classification

C Journal article, C1 Refereed article in a scholarly journal

Copyright notice

2016, Bentham Science

Issue

8

Publisher

Bentham Science