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N-Ethylmaleimide sensitive factor in the cortex of subjects with schizophrenia and bipolar I disorder
N-Ethylmaleimide sensitive factor (NSF) is a presynaptic protein that has been suggested to be differentially expressed in the cortex of schizophrenic subjects through both high-throughput proteomic and genomic screening studies. Thus, to expand upon these studies we measured NSF using Western blotting in four regions of the cortex (BA9, 10, 40 and 46), in a cohort comprising 20 schizophrenic subjects, 8 bipolar I disorder subjects, and 20 control subjects. There was no significant difference in NSF levels between diagnostic cohorts in any of the four cortical regions. These findings highlight the importance of validating findings from high-throughput screening studies and do not support changes in cortical NSF as being of significance in schizophrenia or bipolar 1 disorder.
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Journal
Neuroscience lettersVolume
391Issue
3Pagination
112 - 115Publisher
ElsevierLocation
Amsterdam, The NetherlandsPublisher DOI
ISSN
1872-7972Language
engPublication classification
C1.1 Refereed article in a scholarly journalCopyright notice
2006, EselvierUsage metrics
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