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NTS catecholamine cell recruitment by hemorrhage and hypoxia

Version 2 2024-06-03, 18:47
Version 1 2017-07-24, 09:12
journal contribution
posted on 2024-06-03, 18:47 authored by KM Buller, DW Smith, TA Day
Immunolabelling for Fos and tyrosine hydroxylase was used to determine the patterns of activation of nucleus tractus solitarius catecholamine cells in response to graded levels of hemorrhage (0, 4, 8, 12 and 16 ml/kg) and systemic hypoxia (21, 14, 12, 10 and 8% O2) in conscious rats. Both stimuli elicited graded catecholamine cell recruitment with thresholds of 8 ml/kg and 12% O2. The majority of responsive neurons were A2 noradrenergic rather than C2 adrenergic cells. After hemorrhage most Fos-positive catecholamine cells were found below obex whereas most hypoxia-responsive cells were rostral to obex. These distinctive patterns of catecholamine cell recruitment may explain the differences in neuroendocrine responses to these stimuli.

History

Journal

Neuroreport

Volume

10

Pagination

3853-3856

Location

England

ISSN

0959-4965

Language

eng

Publication classification

CN.1 Other journal article

Issue

18

Publisher

Lippincott Williams & Wilkins