File(s) under permanent embargo
Nano-precipitation : preparation and application in the field of pharmacy
journal contribution
posted on 2016-01-01, 00:00 authored by T T D Tran, Phuong TranPhuong Tran, K T Nguyen, V T TranOver the last 30 years, nanoparticle-based medicine has received tremendous attention due to its advances with smart therapeutics and less toxicity. Few nanomedicine products have been approved for commercial use in the clinic (such as Doxil®, Ambraxane®…). Nanomedicine research is still at its early stage and the preparation of nanoparticles must be carefully considered. Systems involving further increased supersaturation, either via solvent evaporation, temperature reduction or anti-solvent mixture, were suggested to be capable of inducing nanoprecipitation (NPT). Since this technique is straight-forward, fast and easy to duplicate in practice, it is highly preferred and recommended. In this review, the process of NTP was described and discussed in detail. Factors that affect the encapsulation efficiency, the nanoparticle size, the morphology and the stability of nanoparticles prepared by NTP were described. This process is one of the most preferable processes for preparing solid nano-protein due to their elegant techniques that preserve the bioactivity of proteins. Although the production of nanoparticles by this process has not been applied in the pharmaceutical industry due to the organic solvent issue, the production equipment for large-scale has been marketed.
History
Journal
Current pharmaceutical designVolume
22Issue
20Pagination
2997 - 3006Publisher
Bentham Science PublishersLocation
Beijing, ChinaPublisher DOI
ISSN
1381-6128eISSN
1873-4286Language
engPublication classification
C Journal article; C1 Refereed article in a scholarly journalCopyright notice
2016, Bentham Science PublishersUsage metrics
Categories
No categories selectedKeywords
nano-precipitationanti-solventencapsulation efficiencysolid nano-proteinmorphologystabilityScience & TechnologyLife Sciences & BiomedicinePharmacology & PharmacyWATER-SOLUBLE DRUGNANOPRECIPITATION METHODFLASH NANOPRECIPITATIONANTISOLVENT PRECIPITATIONPARTICLE-SIZEEMULSIFICATION-DIFFUSIONSONOPRECIPITATION METHODNANOPARTICLE FORMATIONLOADED NANOCAPSULESPOLYMER PARTICLES
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC