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Nanotechnology in neuroscience and its perspective as gene carrier

Version 2 2024-06-04, 11:45
Version 1 2017-04-07, 13:27
journal contribution
posted on 2024-06-04, 11:45 authored by TMT Khanh, D Wei, PHL Tran, TTD Tran
Gene therapy has a strong potential in neuroscience by suppressing or replacing abnormalities in genetic materials. The employment of nano-gene carrier for neurological disorders is comparatively young and restricted since the aim to effectively deliver therapeutic agents into the central nervous system (CNS) commonly has confronted difficulties of several natural occurring barriers in the body and unfavorable characteristics of pharmaceutical agents. Two major anatomical and biochemical barriers are blood-brain barrier (BBB) and blood-cerebrospinal fluid barrier (BCSFB), which significantly prevent permeation of most drugs and genes to brain parenchyma. In this concern, nanotechnology emerges as an innovative method for transporting therapeutics to the CNS. Diverse nano-systems have been closely investigated, some of which have demonstrated initial success for in vivo studies. The perspectives of nanotechnology for gene therapy would be a promising field to be further explored in the near future.

History

Journal

Current Topics in Medicinal Chemistry

Volume

17

Pagination

1379-1389

Location

United Arab Emirates

ISSN

1568-0266

eISSN

1873-4294

Language

English

Publication classification

C Journal article, C1.1 Refereed article in a scholarly journal

Copyright notice

2017, Bentham Science Publishers

Issue

12

Publisher

BENTHAM SCIENCE PUBL LTD