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Negative Impact of Disorders of Gut-Brain Interaction on Health-Related Quality of Life: Results From the Rome Foundation Global Epidemiology Survey
journal contribution
posted on 2023-05-03, 23:04 authored by SR Knowles, David SkvarcDavid Skvarc, AC Ford, OS Palsson, SI Bangdiwala, AD Sperber, Antonina Mikocka-WalusAntonina Mikocka-WalusBackground & Aims: This study used the database from the Rome Foundation Global Epidemiology Survey to assess the differences in quality of life overall, and by age and sex, across individual disorders of gut-brain interaction (DGBI), gastrointestinal anatomical region(s), and number of overlapping DGBI. Methods: Data were collected via the Internet in 26 countries, using the Rome IV diagnostic questionnaire and a supplemental questionnaire including the Patient-Reported Outcomes Measurement Information Systems Global-10 quality of life measure. Factorial analyses of variance were used to explore physical and mental quality of life, adjusting for multiple comparisons. Results: Among the 54,127 respondents, quality of life deteriorated significantly with increasing number of overlapping DGBI, with respondents reporting ≥2 DGBI having significantly poorer quality of life than those with only 1 DGBI or those without any DGBI. Men with DGBI reported better quality of life than women, and those aged ≥65 years reported better quality of life than those <65 years. Age, sex, number of overlapping DGBI, somatization, anxiety, depression, and functional experiences (concern, embarrassment, or stress associated with bowel functioning) relating to DGBI, were significant predictors of poorer physical and mental quality of life. Conclusions: This study is the most comprehensive assessment of quality of life to date in adults living with a DGBI. It provides a representative picture of DGBI impact on adults in the global adult population and highlights the significant detrimental impact of living with a DGBI on quality of life.
History
Journal
GastroenterologyVolume
164Pagination
655-668.e10Location
United StatesPublisher DOI
ISSN
0016-5085eISSN
1528-0012Language
enIssue
4Publisher
Elsevier BVUsage metrics
Categories
Keywords
AgeDisorders of Gut-Brain InteractionMental HealthQuality of LifeSexAdultMaleHumansFemaleRomeSurveys and QuestionnairesAnxietyBrainBehavioral and Social ScienceDepressionMental health3 Good Health and Well BeingClinical Sciences not elsewhere classifiedNeurosciences not elsewhere classifiedPaediatrics and Reproductive Medicine not elsewhere classified
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