File(s) under permanent embargo
Neural correlates of symptom severity in obsessive-compulsive disorder using magnetization transfer and diffusion tensor imaging
journal contribution
posted on 2020-04-01, 00:00 authored by S Maleki, Y Chye, X Zhang, L Parkes, S R Chamberlain, L F Fontenelle, L Braganza, George YoussefGeorge Youssef, V Lorenzetti, B J Harrison, M Yücel, C SuoRecent neuroimaging studies in OCD have reported structural alterations in the brain, not limited to frontostriatal regions. While Diffusion Tensor Imaging (DTI) is typically used to interrogate WM microstructure in OCD, additional imaging metric, such as Magnetization Transfer Imaging (MTI), allows for further identification of subtle but important structural changes across both GM and WM. In this study, both MTI and DTI were utilised to investigate the structural integrity of the brain, in OCD in relation to healthy controls. 38 adult OCD patients were recruited, along with 41 age- and gender-matched controls. Structural T1, MTI and DTI data were collected. Case-control differences in Magnetization Transfer Ratio (MTR) and DTI metrics (FA, MD) were examined, along with MTR/DTI-related associations with symptom severity in patients. No significant group differences were found across MTR, FA, and MD. However, OCD symptom severity was positively correlated with MTR in a distributed network of brain regions, including the striatum, cingulate, orbitofrontal area and insula. Within the same regions, OCD symptoms were also positively correlated with FA in WM, and negatively correlated with MD in GM. These results indicate a greater degree of myelination in certain cortical and subcortical regions in the more severe cases of OCD.
History
Journal
Psychiatry research - neuroimagingVolume
298Article number
111046Pagination
1 - 8Publisher
ElsevierLocation
Amsterdam, The NetherlandsPublisher DOI
ISSN
0925-4927eISSN
1872-7506Language
engPublication classification
C1 Refereed article in a scholarly journalUsage metrics
Categories
No categories selectedKeywords
Science & TechnologyLife Sciences & BiomedicineClinical NeurologyNeuroimagingPsychiatryNeurosciences & NeurologyMagnetization transfer imagingObsessive-Compulsive disorderDiffusion tensor imagingMTIOCDDTIWHITE-MATTER ABNORMALITIESFRACTIONAL ANISOTROPYFUNCTIONAL CONNECTIVITYGRAY-MATTERINVENTORYVALIDATIONMTRMICROSTRUCTUREDIMENSIONS
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC