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Neurite density index is sensitive to age related differences in the developing brain
journal contributionposted on 2017-03-01, 00:00 authored by Sila Genc, Charles B Malpas, Scott K Holland, Richard Beare, Tim SilkTim Silk
PURPOSE: White matter development during childhood and adolescence is characterised by increasing white matter coherence and organisation. Commonly used scalar metrics, such as fractional anisotropy (FA), are sensitive to multiple mechanisms of white matter change and therefore unable to distinguish between mechanisms that change during development. We investigate the relationship between age and neurite density index (NDI) from neurite orientation dispersion and density imaging (NODDI), and the age-classification accuracy of NDI compared with FA, in a developmental cohort. METHOD: Diffusion-weighted imaging data from 72 children and adolescents between the ages of 4-19 was collected (M=10.42, SD=3.99, 36 male). We compared NODDI metrics against conventional DTI metrics (fractional anisotropy [FA], mean diffusivity [MD], axial diffusivity [AD] and radial diffusivity [RD]) in terms of their relationship to age. An ROC analysis was also performed to assess the ability of each metric to classify older and younger participants. RESULTS: NDI exhibited a stronger relationship with age (median R2=.60) compared with MD (median R2=.39), FA (median R2=.27), AD (median R2=.14), and RD (median R2=.35) in a high proportion of white matter tracts. When participants were divided into an older and younger group, NDI achieved the best classification (median area under the curve [AUC]=.89), followed by MD (median AUC=.81), FA (median AUC=.80), RD (median AUC=.81), and AD (median AUC=.64). CONCLUSION: Our results demonstrate the sensitivity of NDI to age-related differences in white matter microstructural organisation over development. Importantly, NDI is more sensitive to such developmental changes compared to commonly used DTI metrics. This knowledge provides justification for implementing NODDI metrics in developmental studies.
Pagination373 - 380
LocationAmsterdam, The Netherlands
Publication classificationC1 Refereed article in a scholarly journal
Copyright notice2017, Elsevier Inc.
CategoriesNo categories selected
AgeDTIDevelopmentNODDINeurite densityWhite matterAdolescentAgingAnisotropyBrainChildChild, PreschoolDiffusion Tensor ImagingFemaleHumansImage Processing, Computer-AssistedMaleModels, NeurologicalNeuritesNeuroimagingYoung AdultScience & TechnologyLife Sciences & BiomedicineNeurosciencesRadiology, Nuclear Medicine & Medical ImagingNeurosciences & NeurologyWHITE-MATTER MICROSTRUCTUREORIENTATION DISPERSIONLANGUAGE LATERALIZATIONSEX-DIFFERENCESDIFFUSION MRILIFE-SPANIN-VIVOCHILDRENADULTS