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Neurodevelopmental pathways in bipolar disorder

Version 2 2024-05-30, 15:24
Version 1 2020-03-12, 14:26
journal contribution
posted on 2024-05-30, 15:24 authored by S Kloiber, JD Rosenblat, MI Husain, A Ortiz, Michael BerkMichael Berk, J Quevedo, E Vieta, M Maes, B Birmaher, JC Soares, AF Carvalho
Aberrations in neurodevelopmental trajectories have been implicated in the neurobiology of several mental disorders and evidence indicates a pathophysiological and genetic overlap of schizophrenia and bipolar disorder (BD). In this narrative review, we summarize findings related to developmental and perinatal factors as well as epidemiological, clinical, neuropsychological, brain imaging, postmortem brain and genomic studies that provide evidence for a putative neurodevelopmental pathogenesis and etiology of BD. Overall, aberrations in neurodevelopmental pathways have been more consistently implicated in the pathophysiology of schizophrenia compared to BD. Nevertheless, an accumulating body of evidence indicates that dysfunctional neurodevelopmental pathways may be implicated in the underlying pathophysiology of at least a subset of individuals with BD particularly those with an early age of illness onset and those exhibiting psychotic symptoms. A heuristic neurodevelopmental model for the pathophysiology of BD based on the findings of this review is proposed. Furthermore, we critically discuss clinical and research implications of this model. Finally, further research directions for this emerging field are provided.

History

Journal

Neuroscience and Biobehavioral Reviews

Volume

112

Pagination

213-226

Location

Amsterdam, The Netherlands

ISSN

0149-7634

eISSN

1873-7528

Language

eng

Publication classification

C1 Refereed article in a scholarly journal

Copyright notice

2020, Elsevier Ltd

Publisher

Elsevier