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Neuroimaging genomic studies in major depressive disorder: a systematic review

journal contribution
posted on 01.11.2018, 00:00 authored by Hui-Feng Zhang, David MellorDavid Mellor, Dai-Hui Peng
Genetic-neuroimaging studies could identify new potential endophenotypes of major depressive disorder (MDD). Morphological and functional alterations may be attributable to genetic factors that regulate neurogenesis and neurodegeneration. Given that the association between gene polymorphisms and brain morphology or function has varied across studies, this systematic review aims at evaluating and summarizing all available genetic-neuroimaging studies. Twenty-eight gene variants were evaluated in 64 studies by structural or functional magnetic resonance imaging. Significant genetic-neuroimaging associations were found in monoaminergic genes, BDNF genes, glutamatergic genes, HPA axis genes, and the other common genes, which were consistent with common hypotheses of the pathogenesis of MDD.

History

Journal

CNS neuroscience and therapeutics

Volume

24

Issue

11

Season

Special Issue on Imaging Connectomics in Depression

Pagination

1020 - 1036

Publisher

John Wiley & Sons

Location

Chichester, Eng.

eISSN

1755-5949

Language

eng

Publication classification

C1 Refereed article in a scholarly journal

Copyright notice

2018, John Wiley & Sons Ltd