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Neurotrophins, inflammation and oxidative stress as illness activity biomarkers in bipolar disorder
journal contribution
posted on 2022-12-01, 04:21 authored by B Pfaffenseller, G R Fries, B Wollenhaupt-Aguiar, G D Colpo, L Stertz, B Panizzutti, P V Magalhães, F KapczinskiRecent studies highlight the presence of systemic toxicity as an integral dimension of bipolar disorder pathophysiology, possibly linking this mood disorder with other medical conditions and comorbidities. This review summarizes recent findings on possible peripheral biomarkers of illness activity, with a focus on neurotrophins, inflammation and oxidative stress. The possible mechanisms underlying the systemic toxicity associated with acute episodes in bipolar disorder are also discussed. Finally, the authors outline novel therapies that emerge from this new research and the assessment of multiple biomarkers as a potential approach to improving management strategies in bipolar disorder. © 2013 2013 Informa UK Ltd.
History
Journal
Expert Review of NeurotherapeuticsVolume
13Pagination
827 - 842Publisher DOI
ISSN
1473-7175eISSN
1744-8360Publication classification
C1.1 Refereed article in a scholarly journalUsage metrics
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No categories selectedKeywords
Science & TechnologyLife Sciences & BiomedicineClinical NeurologyPharmacology & PharmacyNeurosciences & Neurologybipolar disorderendoplasmic reticulum stressglial dysfunctionillness activityinflammationmitochondrial dysfunctionneurotrophinsnovel therapiesoxidative stressperipheral biomarkerssystemic toxicityENDOPLASMIC-RETICULUM STRESSN-ACETYL CYSTEINEUNFOLDED PROTEIN RESPONSEDECREASED BDNF LEVELSVS. LATE-STAGESUPEROXIDE-DISMUTASEDEPRESSIVE EPISODESGENE-EXPRESSIONDOUBLE-BLINDSERUM-LEVELS
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