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New and improved 'LEGO' BLOCK protocols for the direct synthesis of hydrophilic ribbon molecules with acid, ester or peptide functionality

Version 2 2024-06-04, 02:35
Version 1 2017-05-09, 15:40
journal contribution
posted on 2024-06-04, 02:35 authored by RN Warrener, DN Butler, D Margetic, Fred PfefferFred Pfeffer, RA Russell
Hydrophilic ribbon molecules are produced directly from the reaction of cyclobutene epoxide BLOCKs with norbornene dipolarophiles or indirectly by chemical modification of substituents in preformed lipophilic ribbon molecules. The formation of di- and tetra-acid chloride epoxides holds the key to the formation of ester, acid and amide BLOCKs which are active in 1,3- dipolar cycloadditions with norbornene dipolarophiles, thereby delivering a wide range of substituents into the ribbon molecules and opening up combinatorial opportunities at each step.

History

Journal

Tetrahedron letters

Volume

41

Pagination

4671-4675

Location

Amsterdam, The Netherlands

ISSN

0040-4039

Language

eng

Publication classification

C1.1 Refereed article in a scholarly journal

Copyright notice

2000, Elsevier Science

Issue

23

Publisher

Elsevier Science