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New drug candidates for bipolar disorder—A nation-wide population-based study

Version 2 2024-06-06, 09:35
Version 1 2019-04-11, 15:32
journal contribution
posted on 2024-06-06, 09:35 authored by LV Kessing, HC Rytgaard, TA Gerds, Michael BerkMichael Berk, CT Ekstrøm, PK Andersen
OBJECTIVE: Drug repurposing is an increasingly promising idea in many fields of medicine. We systematically used Danish nation-wide population-based registers to investigate whether continued use of non-aspirin non-steroidal anti-inflammatory drugs (NSAIDs), low-dose aspirin, high-dose aspirin, statins, allopurinol, and angiotensin agents decrease the rate of incident mania/bipolar disorder. METHODS: A nation-wide population-based longitudinal study using Poisson regression analyses including all persons in Denmark who purchased the exposure medication of interest and a random sample of 30% of the Danish population. The follow-up period comprised a 10 years period from 2005 to 2015. Two different outcome measures were included, (1) a diagnosis of mania/bipolar disorder at a psychiatric hospital contact as inpatient or outpatient and (2) a combined measure of a diagnosis of mania/bipolar disorder or initiation of lithium use. RESULTS: A total of 1,605,365 subjects were exposed to one of the six drugs of interest during the exposure period from 2005 to 2015, median age 57 years [quartiles: 43;69], and female proportion of 53.1%. Continued use of low-dose aspirin, statins, and angiotensin agents were associated with decreased rates of incident mania/bipolar disorder on both outcome measures. Continued uses of non-aspirin NSAIDs as well as high-dose aspirin were associated with an increased rate of incident bipolar disorder. There were no statistically significant associations for allopurinol. CONCLUSIONS: The study supports the potential of agents acting on inflammation and the stress response system in bipolar disorder and illustrates that population-based registers can be used to systematically identify drugs with repurposing potentials.

History

Journal

Bipolar Disorders

Volume

21

Pagination

410-418

Location

Denmark

ISSN

1398-5647

eISSN

1399-5618

Language

English

Publication classification

C1 Refereed article in a scholarly journal

Copyright notice

2019, John Wiley & Sons

Issue

5

Publisher

WILEY