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New insights into CNS requirements for the copper-ATPase, ATP7A. Focus on "Autonomous requirements of the Menkes disease protein in the nervous system".

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journal contribution
posted on 2015-12-01, 00:00 authored by Sharon La FontaineSharon La Fontaine
copper is indispensable for development and function of the central nervous system (CNS). This is dramatically illustrated by the severe neuropathological deficits in Menkes disease, an X-linked copper deficiency disorder resulting from mutation of the gene that encodes an essential copper transporting P1B-type ATPase, ATP7A. Since its discovery over two decades ago, the role of ATP7A in copper transport and homeostasis has been inextricably linked to satisfying systemic and CNS requirements for copper. In a recent issue of American Journal of Physiology-Cell Physiology, Hodgkinson et al. (8) describe an important body of work, which for the first time distinguishes the CNS requirement for ATP7A from the CNS requirement for copper.

History

Journal

American journal of physiology: cell physiology

Volume

309

Pagination

C719-C721

Location

Bethesda, Maryland

Open access

  • Yes

ISSN

1522-1563

eISSN

1522-1563

Language

eng

Publication classification

C Journal article, C4.1 Letter or note

Copyright notice

2015, American Physiological Society

Issue

11

Publisher

American Physiological Society