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New pH-responsive gemini lipid derived co-liposomes for efficacious doxorubicin delivery to drug resistant cancer cells

journal contribution
posted on 2017-07-25, 00:00 authored by P Moitra, K Kumar, S Sarkar, P Kondaiah, Wei DuanWei Duan, S Bhattacharya
A gemini version of the amphiphile palmitoyl homocysteine was synthesized. Co-liposomes were prepared using the gemini along with a natural zwitterionic lipid, DOPE and cholesterol at specified ratios. This afforded pH-responsive co-liposomes which could efficiently transport the anticancer drug, doxorubicin (DOX), across the DOX-resistant HeLa cancer cells in response to low pH of cellular endosomes.

History

Journal

Chemical communications

Volume

53

Issue

58

Pagination

8184 - 8187

Publisher

Royal Society of Chemistry

Location

Cambridge, Eng.

Publisher DOI

eISSN

1364-548X

Language

eng

Publication classification

C Journal article; C1 Refereed article in a scholarly journal

Copyright notice

2017, The Royal Society of Chemistry

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    Keywords

    Chemistrygemini versionpalmitoyl homocysteineCo-liposomesanticancer drugdoxorubicin (DOX)HeLa cancer cellscellular endosomesScience & TechnologyPhysical SciencesChemistry, MultidisciplinaryCATIONIC LIPIDSVESICLE FORMATIONSENSITIVE IMMUNOLIPOSOMESMOLECULAR DESIGNGENE DELIVERYPLASMID DNAACIDRELEASESERUMNANOPARTICLES

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