File(s) under permanent embargo
New pH-responsive gemini lipid derived co-liposomes for efficacious doxorubicin delivery to drug resistant cancer cells
journal contribution
posted on 2017-07-25, 00:00 authored by P Moitra, K Kumar, S Sarkar, P Kondaiah, Wei DuanWei Duan, S BhattacharyaA gemini version of the amphiphile palmitoyl homocysteine was synthesized. Co-liposomes were prepared using the gemini along with a natural zwitterionic lipid, DOPE and cholesterol at specified ratios. This afforded pH-responsive co-liposomes which could efficiently transport the anticancer drug, doxorubicin (DOX), across the DOX-resistant HeLa cancer cells in response to low pH of cellular endosomes.
History
Journal
Chemical communicationsVolume
53Issue
58Pagination
8184 - 8187Publisher
Royal Society of ChemistryLocation
Cambridge, Eng.Publisher DOI
eISSN
1364-548XLanguage
engPublication classification
C Journal article; C1 Refereed article in a scholarly journalCopyright notice
2017, The Royal Society of ChemistryUsage metrics
Read the peer-reviewed publication
Categories
Keywords
Chemistrygemini versionpalmitoyl homocysteineCo-liposomesanticancer drugdoxorubicin (DOX)HeLa cancer cellscellular endosomesScience & TechnologyPhysical SciencesChemistry, MultidisciplinaryCATIONIC LIPIDSVESICLE FORMATIONSENSITIVE IMMUNOLIPOSOMESMOLECULAR DESIGNGENE DELIVERYPLASMID DNAACIDRELEASESERUMNANOPARTICLES