Deakin University
Browse

File(s) under permanent embargo

Non-Hodgkin's lymphoma and hepatitis C virus infection

Version 2 2024-06-03, 18:07
Version 1 2019-07-22, 09:44
journal contribution
posted on 2024-06-03, 18:07 authored by AM Brind, Jon WatsonJon Watson, A Burt, P Kestevan, J Wallis, SJ Proctor, MF Bassendine
The hepatitis C virus (HCV) is a recently described and important cause of acute and chronic liver disease. A hallmark of HCV is its propensity to become chronic, some patients with chronic HCV progressing to cirrhosis and hepatocellular carcinoma (HCC). HCV is also lymphotrophic and we report 2 patients with HCV cirrhosis who developed non-Hodgkins lymphoma (NHL). These cases raise the possibility that chronic HCV infection of lymphocytes plays an aetiological role in this malignancy. However screening of a further 63 consecutive patients over the age of 50 years with NHL for HCV antibody by second generation enzyme linked immunoassay (ELISA) failed to identify any patients with evidence of HCV infection. This suggests that HCV is an uncommon contributory factor for the development of non-Hodgkins lymphoma in the United Kingdom.

History

Journal

Leukemia and lymphoma

Volume

21

Pagination

127-130

Location

Abingdon, Eng.

ISSN

1042-8194

Language

eng

Publication classification

C1.1 Refereed article in a scholarly journal

Copyright notice

1996, Taylor & Francis

Issue

1-2

Publisher

Taylor & Francis

Usage metrics

    Research Publications

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC