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Non-invasive assessment of dorsiflexor muscle function in mice

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Version 2 2024-06-04, 03:43
Version 1 2019-02-27, 15:37
journal contribution
posted on 2024-06-04, 03:43 authored by F Gerlinger-Romero, AB Addinsall, RM Lovering, VC Foletta, C Van Der Poel, PA Della-Gatta, Aaron RussellAaron Russell
Assessment of skeletal muscle contractile function is an important measurement for both clinical and research purposes. Numerous conditions can negatively affect skeletal muscle. This can result in a loss of muscle mass (atrophy) and/or loss of muscle quality (reduced force per unit of muscle mass), both of which are prevalent in chronic disease, muscle-specific disease, immobilization, and aging (sarcopenia). Skeletal muscle function in animals can be evaluated by a range of different tests. All tests have limitations related to the physiological testing environment, and the selection of a specific test often depends on the nature of the experiments. Here, we describe an in vivo, non-invasive technique involving a helpful and easy assessment of force frequency-curve (FFC) in mice that can be performed on the same animal over time. This permits monitoring of disease progression and/or efficacy of a potential therapeutic treatment.

History

Journal

Journal of Visualized Experiments

Volume

2019

Article number

ARTN e58696

Pagination

1 - 6

Location

United States

Open access

  • Yes

ISSN

1940-087X

eISSN

1940-087X

Language

English

Publication classification

C1 Refereed article in a scholarly journal

Copyright notice

2019, the authors

Issue

143

Publisher

JOURNAL OF VISUALIZED EXPERIMENTS