Version 2 2024-06-04, 03:43Version 2 2024-06-04, 03:43
Version 1 2019-02-27, 15:37Version 1 2019-02-27, 15:37
journal contribution
posted on 2024-06-04, 03:43authored byF Gerlinger-Romero, AB Addinsall, RM Lovering, VC Foletta, C Van Der Poel, PA Della-Gatta, Aaron RussellAaron Russell
Assessment of skeletal muscle contractile function is an important measurement for both clinical and research purposes. Numerous conditions can negatively affect skeletal muscle. This can result in a loss of muscle mass (atrophy) and/or loss of muscle quality (reduced force per unit of muscle mass), both of which are prevalent in chronic disease, muscle-specific disease, immobilization, and aging (sarcopenia). Skeletal muscle function in animals can be evaluated by a range of different tests. All tests have limitations related to the physiological testing environment, and the selection of a specific test often depends on the nature of the experiments. Here, we describe an in vivo, non-invasive technique involving a helpful and easy assessment of force frequency-curve (FFC) in mice that can be performed on the same animal over time. This permits monitoring of disease progression and/or efficacy of a potential therapeutic treatment.