russell-noninvasive-2019.pdf (1.16 MB)
Download fileNon-invasive assessment of dorsiflexor muscle function in mice
journal contribution
posted on 2019-01-01, 00:00 authored by Frederico Gerlinger Romero, Alex Addinsall, Richard M Lovering, Victoria Foletta, Chris van der Poel, Paul Della GattaPaul Della Gatta, Aaron RussellAaron RussellAssessment of skeletal muscle contractile function is an important measurement for both clinical and research purposes. Numerous conditions can negatively affect skeletal muscle. This can result in a loss of muscle mass (atrophy) and/or loss of muscle quality (reduced force per unit of muscle mass), both of which are prevalent in chronic disease, muscle-specific disease, immobilization, and aging (sarcopenia). Skeletal muscle function in animals can be evaluated by a range of different tests. All tests have limitations related to the physiological testing environment, and the selection of a specific test often depends on the nature of the experiments. Here, we describe an in vivo, non-invasive technique involving a helpful and easy assessment of force frequency-curve (FFC) in mice that can be performed on the same animal over time. This permits monitoring of disease progression and/or efficacy of a potential therapeutic treatment.
History
Journal
Journal of visualized experimentsIssue
143Article number
e58696Pagination
1 - 6Publisher
JOVELocation
United StatesPublisher DOI
Link to full text
eISSN
1940-087XLanguage
engPublication classification
C1 Refereed article in a scholarly journalCopyright notice
2019, the authorsUsage metrics
Read the peer-reviewed publication
Categories
Keywords
skeletal muscle contractile functionskeletal muscleloss of muscle mass (atrophy)loss of muscle qualityMedicineIssue 143Dorsiflexionmuscle functionin vivotibialis anteriorextensor digitorum longusmicenon-invasive testScience & TechnologyMultidisciplinary SciencesScience & Technology - Other TopicsSKELETAL-MUSCLE