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Non-invasive assessment of dorsiflexor muscle function in mice

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journal contribution
posted on 01.01.2019, 00:00 authored by Frederico Gerlinger Romero, Alex Addinsall, Richard M Lovering, Victoria Foletta, Chris van der Poel, Paul Della GattaPaul Della Gatta, Aaron RussellAaron Russell
Assessment of skeletal muscle contractile function is an important measurement for both clinical and research purposes. Numerous conditions can negatively affect skeletal muscle. This can result in a loss of muscle mass (atrophy) and/or loss of muscle quality (reduced force per unit of muscle mass), both of which are prevalent in chronic disease, muscle-specific disease, immobilization, and aging (sarcopenia). Skeletal muscle function in animals can be evaluated by a range of different tests. All tests have limitations related to the physiological testing environment, and the selection of a specific test often depends on the nature of the experiments. Here, we describe an in vivo, non-invasive technique involving a helpful and easy assessment of force frequency-curve (FFC) in mice that can be performed on the same animal over time. This permits monitoring of disease progression and/or efficacy of a potential therapeutic treatment.

History

Journal

Journal of visualized experiments

Issue

143

Article number

e58696

Pagination

1 - 6

Publisher

JOVE

Location

United States

eISSN

1940-087X

Language

eng

Publication classification

C1 Refereed article in a scholarly journal

Copyright notice

2019, the authors