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Nonribosomal peptides from marine microbes and their antimicrobial and anticancer potential

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journal contribution
posted on 2017-11-01, 00:00 authored by Shivankar Agrawal, D Acharya, Alok AdholeyaAlok Adholeya, Colin BarrowColin Barrow, S K Deshmukh
Marine environments are largely unexplored and can be a source of new molecules for the treatment of many diseases such as malaria, cancer, tuberculosis, HIV etc. The Marine environment is one of the untapped bioresource of getting pharmacologically active nonribosomal peptides (NRPs). Bioprospecting of marine microbes have achieved many remarkable milestones in pharmaceutics. Till date, more than 50% of drugs which are in clinical use belong to the nonribosomal peptide or mixed polyketide-nonribosomal peptide families of natural products isolated from marine bacteria, cyanobacteria and fungi. In recent years large numbers of nonribosomal have been discovered from marine microbes using multi-disciplinary approaches. The present review covers the NRPs discovered from marine microbes and their pharmacological potential along with role of genomics, proteomics and bioinformatics in discovery and development of nonribosomal peptides drugs.

History

Journal

Frontiers in pharmacology

Volume

8

Article number

828

Pagination

1 - 26

Publisher

Frontiers Media

Location

Lausanne, Switzerland

ISSN

1663-9812

Language

eng

Publication classification

C Journal article; C1 Refereed article in a scholarly journal

Copyright notice

2017, Agrawal, Acharya, Adholeya, Barrow and Deshmukh