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Norbornene-based anion receptors as D-alanine binders

journal contribution
posted on 2015-01-01, 00:00 authored by Benjamin Long, Fred PfefferFred Pfeffer
Vancomycin is currently used as last-line therapy against many Gram-positive bacterial pathogens. Herein, we report a series of peptidomimetic norbornene-based anion receptors that were designed as simple vancomycin mimics New hosts were evaluated for their affinity to both acetate and acetyl D-Ala by 1H NMR titration. Modest binding to both anions was observed in DMSO-d6 (Log Ka 1-2 for TBA Acetyl D-Alanine) in the anticipated 1:1 mode of binding.

History

Journal

Supramolecular chemistry

Volume

27

Issue

11-12

Pagination

847 - 853

Publisher

Taylor & Francis

Location

London, Eng.

ISSN

1061-0278

eISSN

1029-0478

Language

eng

Publication classification

C Journal article; C1 Refereed article in a scholarly journal

Copyright notice

2015, Taylor & Francis

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