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Novel endoperoxides: synthesis and activity against Candida species

journal contribution
posted on 2006-02-15, 00:00 authored by Peter Macreadie, T Avery, B Greatrex, D Taylor, I Macreadie
Fifteen new endoperoxides have been synthesised and tested for activity against pathogenic Candida species. These endoperoxides can be prepared in high yields, in one to three steps, from inexpensive starting materials. Despite chemical and structural similarities, their inhibitory activity against Candida growth varied greatly from one endoperoxide to another, and one species to another. This study of susceptibility to endoperoxide compounds presented here may lead to the development of potent new antifungal agents.

History

Journal

Bioorganic & medicinal chemistry letters

Volume

16

Pagination

920-922

Location

Amsterdam, The Netherlands

ISSN

0960-894X

Language

eng

Publication classification

C1.1 Refereed article in a scholarly journal

Copyright notice

2006, Elsevier

Issue

4

Publisher

Elsevier