Novel endoperoxides: synthesis and activity against Candida species
journal contribution
posted on 2006-02-15, 00:00authored byPeter Macreadie, T Avery, B Greatrex, D Taylor, I Macreadie
Fifteen new endoperoxides have been synthesised and tested for activity against pathogenic Candida species. These endoperoxides can be prepared in high yields, in one to three steps, from inexpensive starting materials. Despite chemical and structural similarities, their inhibitory activity against Candida growth varied greatly from one endoperoxide to another, and one species to another. This study of susceptibility to endoperoxide compounds presented here may lead to the development of potent new antifungal agents.