Novel Measures of Similarity and Asymmetry in Upper Limb Activities for Identifying Hemiparetic Severity in Stroke Survivors

Stroke survivors are often characterized by hemiparesis , i.e. , paralysis in one half of the body, severely affecting upper limb movements. Monitoring the progression of hemiparesis requires manual observation of limb movements at regular intervals, and hence is a labour intensive process. In this work, we use wrist-worn accelerometers for automated assessment of hemiparesis in acute stroke. We propose novel measures of similarity and asymmetry in hand activities through bivariate Poincaré analysis between two-hand accelerometer data for quantifying hemiparetic severity. The proposed descriptors characterize the distribution of activity surrogates derived from acceleration of the two hands, on a 2D bivariate Poincaré Plot. Experiments show that while the descriptors CSD1 and CSD2 can identify hemiparetic patients from control subjects, their normalized difference CSDR and the descriptors Complex Cross-Correlation Measure ( C3M ) and Activity Asymmetry Index ( AAI ) can distinguish between mild , moderate and severe hemiparesis. These measures are compared with traditional measures of cross-correlation and evaluated against the National Institutes of Health Stroke Scale (NIHSS), the clinical gold standard for hemiparetic severity estimation. This study, undertaken on 40 acute stroke patients with varying levels of hemiparesis and 15 healthy controls, validates the use of short length ( < 5 minutes) wearable accelerometry data for identifying hemiparesis with greater clinical sensitivity. Results show that the proposed descriptors with a hierarchical classification model outperform state-of-the-art methods with overall accuracy of 0.78 and 0.85 for 4-class and 3-class hemiparesis identification respectively.