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Number of lifetime menses increases breast cancer occurrence in postmenopausal women at high familial risk

journal contribution
posted on 2023-03-06, 04:44 authored by M Bieuville, D Faugère, V Galibert, M Henard, Antoine DujonAntoine Dujon, Beata UjvariBeata Ujvari, P Pujol, B Roche, F Thomas
It is increasingly thought that part of human susceptibility to cancer is the result of evolutionary mismatches: our ancestors evolved cancer suppression mechanisms in a world largely different from our modern environments. In that context, it has been shown in cohorts from general Western populations that reproductive traits modulate breast cancer risk. Overall, the more menses women experience, the more at risk they are to develop postmenopausal breast cancer. This points towards an evolutionary mismatch but brings the question whether the reproductive pattern also modulates the breast cancer risk in menopausal women at high familial risk. We thus studied the influence of menses on breast cancer risk in a case–control study of 90 postmenopausal women (including BRCA1/2 and non BRCA1/2) nested within a cohort at high familial risk. We tested the association of the lifetime number of menses and the number of menses before first full-term pregnancy with postmenopausal breast cancer risk using Cox survival models. We showed that the total lifetime number of menses was significantly associated with postmenopausal breast cancer risk and associated with a quicker onset of breast cancer after menopause. Those results align with similar studies lead in general cohorts and suggest that the reproductive pattern modulates the familial risk of developing breast cancer after menopause. Altogether, those results impact how we envision breast cancer prevention and call for more research on how ecological and genetic factors shape breast cancer risk.

History

Journal

Frontiers in Ecology and Evolution

Volume

11

Pagination

1-9

Location

Lausanne, Switzerland

ISSN

2296-701X

eISSN

2296-701X

Language

eng

Publication classification

C1 Refereed article in a scholarly journal

Publisher

Frontiers Media SA