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Nutrient intake in the bovine during early and mid-gestation causes sex-specific changes in progeny plasma IGF-I, liveweight, height and carcass traits
journal contribution
posted on 2010-09-01, 00:00 authored by G C Micke, T M Sullivan, K L Gatford, Julie OwensJulie Owens, V E A PerryFetal and postnatal growth are mediated by insulin-like growth factors (IGFs) and their binding proteins (IGFBPs). Maternal nutrient intake during gestation can program the postnatal IGF-axis. This may have significant economic implications for beef cattle production. We investigated the effect of high (H=240%) and low (L=70%) levels of recommended daily crude protein (CP) intake for heifers during the first and second trimesters of gestation in a two-by-two factorial design on progeny (n=68) plasma IGF-I, IGF-II, total IGFBP (tIGFBP), postnatal growth and carcass traits. Calves were heavier at birth following high CP diets during the second trimester (P=0.03) and this persisted to 29d. Plasma IGF-I concentrations of males were greater for HL compared to LL (P<0.01) and HH (P>0.04) from 29 to 657d, and for LH compared to LL from 29 until 379d (P=0.02). Exposure to low CP diets during the first trimester resulted in heavier males from 191d onwards (P=0.04) but a tendency for lighter females from 552d onwards (P=0.07) that had lighter carcass weights (P=0.04). Longissimus dorsi cross-sectional area of all carcasses was greater following exposure to low CP diets during the second trimester (P=0.04). Heifer nutrient intake during the first and second trimesters causes persistent and sex-specific programming of progeny plasma IGF-I, postnatal liveweight and carcass weight. Refining heifer nutritional programs during early gestation may optimize production objectives in progeny.
History
Journal
Animal reproduction scienceVolume
121Issue
3-4Pagination
208 - 217Publisher
ElsevierLocation
Amsterdam, The NetherlandsPublisher DOI
eISSN
1873-2232Language
engPublication classification
C1.1 Refereed article in a scholarly journalCopyright notice
2010, Elsevier B.V.Usage metrics
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AnimalsBody SizeBody WeightCattleDietary ProteinsFatty Acids, NonesterifiedFemaleGestational AgeInsulin-Like Growth Factor Binding Protein 1Insulin-Like Growth Factor IInsulin-Like Growth Factor IIMaleMaternal Nutritional Physiological PhenomenaPregnancyPrenatal Exposure Delayed EffectsSex CharacteristicsUreaFetal programmingIGFMaternal nutritionMetabolitesPostnatal growthScience & TechnologyLife Sciences & BiomedicineAgriculture, Dairy & Animal ScienceReproductive BiologyVeterinary SciencesAgricultureGROWTH-FACTOR-IADIPOSE-TISSUE DEVELOPMENTMATERNAL NUTRITION ALTERSMESSENGER-RNA EXPRESSIONFACTOR BINDING-PROTEINSFETAL SKELETAL-MUSCLELATE-GESTATIONPOSTNATAL-GROWTHBIRTH-WEIGHTOVINE FETUS
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