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Nutrition support use and clinical outcomes in patients with multiple myeloma undergoing autologous stem cell transplant
journal contribution
posted on 2023-02-10, 05:07 authored by J Kuypers, N Simmance, H Quach, K Hastie, Nicole KissNicole KissPurpose: Malnutrition is associated with worse outcomes post-haematopoietic stem cell transplantation, with nutrition support recommended for people who are malnourished or have prolonged inadequate energy intake. We investigated associations between nutritional status, nutrition support type and clinical outcomes in adults with multiple myeloma post stem cell transplantation. Methods: Medical records (2015–2020) were reviewed to retrieve demographics, anthropometry, dietary data, nutrition support type (enteral/oral versus parenteral), and clinical outcomes (engraftment time, infection, length of stay, weight changes). Relationships were examined using linear regression modelling and Fisher’s exact test. Results: One hundred thirteen participants were included (61% male; median age 62 years). Fifteen participants (13%) received parenteral and 98 (87%) received enteral/oral nutrition support. Parenteral nutrition was associated with shorter platelet engraftment time by 2.7 days (p = 0.036) and a longer hospital stay by 6.1 days (p < 0.001). Nutrition support was not associated with neutrophil engraftment time (p = 0.365). Inadequate energy intake for ≥ 7 days was not associated with any clinical outcomes (p > 0.05). Conclusions: Participants who received parenteral nutrition reached platelet engraftment sooner but were in hospital longer. Inadequate energy intake for ≥ 7 days did not impact clinical outcomes. Multi-site prospective studies are warranted to confirm results.
History
Journal
Supportive Care in CancerVolume
30Pagination
9341-9350Location
GermanyPublisher DOI
ISSN
0941-4355eISSN
1433-7339Language
EnglishPublication classification
C1 Refereed article in a scholarly journalIssue
11Publisher
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No categories selectedKeywords
Science & TechnologyLife Sciences & BiomedicineOncologyHealth Care Sciences & ServicesRehabilitationNutrition supportEnteral nutritionParenteral nutritionMultiple myelomaAutologous stem cell transplantSUBJECTIVE GLOBAL ASSESSMENTMALNUTRITION SCREENING TOOLCANCERENGRAFTMENTGUIDELINESAdultHumansMaleMiddle AgedFemaleMultiple MyelomaHematopoietic Stem Cell TransplantationParenteral NutritionNutritional SupportMalnutritionStem Cell TransplantationStem Cell ResearchHematologyTransplantationNutritionClinical ResearchRegenerative MedicineCancerMetabolic and endocrine2 Zero HungerMedical and Health SciencesPsychology and Cognitive Sciences
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