jacka-nutritionalpsychiatry-2017.pdf (382.85 kB)
Nutritional psychiatry: where to next?
The nascent field of 'Nutritional Psychiatry' offers much promise for addressing the large disease burden associated with mental disorders. A consistent evidence base from the observational literature confirms that the quality of individuals' diets is related to their risk for common mental disorders, such as depression. This is the case across countries and age groups. Moreover, new intervention studies implementing dietary changes suggest promise for the prevention and treatment of depression. Concurrently, data point to the utility of selected nutraceuticals as adjunctive treatments for mental disorders and as monotherapies for conditions such as ADHD. Finally, new studies focused on understanding the biological pathways that mediate the observed relationships between diet, nutrition and mental health are pointing to the immune system, oxidative biology, brain plasticity and the microbiome-gut-brain axis as key targets for nutritional interventions. On the other hand, the field is currently limited by a lack of data and methodological issues such as heterogeneity, residual confounding, measurement error, and challenges in measuring and ensuring dietary adherence in intervention studies. Key challenges for the field are to now: replicate, refine and scale up promising clinical and population level dietary strategies; identify a clear set of biological pathways and targets that mediate the identified associations; conduct scientifically rigorous nutraceutical and 'psychobiotic' interventions that also examine predictors of treatment response; conduct observational and experimental studies in psychosis focused on dietary and related risk factors and treatments; and continue to advocate for policy change to improve the food environment at the population level.
History
Journal
EBioMedicineVolume
17Pagination
24 - 29Publisher
ElsevierLocation
Amsterdam, The NetherlandsPublisher DOI
eISSN
2352-3964Language
engPublication classification
C Journal article; C1 Refereed article in a scholarly journalCopyright notice
2017, The AuthorsUsage metrics
Categories
No categories selectedKeywords
DepressionDietMental disorderNeurodegenerativeNeurodevelopmentNutraceuticalNutritionPreventionPsychosisTreatmentAnimalsAttention Deficit Disorder with HyperactivityDiet TherapyDietary SupplementsHumansScience & TechnologyLife Sciences & BiomedicineMedicine, General & InternalMedicine, Research & ExperimentalGeneral & Internal MedicineResearch & Experimental MedicineMAJOR DEPRESSIVE DISORDERPRELIMINARY DOUBLE-BLINDMENTAL-HEALTH PROBLEMSTERM DIETARY PATTERNSGUT MICROBIOTABIPOLAR DISORDERCONTROLLED-TRIALVEGETABLE CONSUMPTIONCOGNITIVE IMPAIRMENTMEDITERRANEAN DIET
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC