Deakin University
Browse

Obesity blunts microvascular recruitment in human forearm muscle after a mixed meal

Download (480.45 kB)
Version 2 2024-06-04, 12:42
Version 1 2017-03-22, 16:20
journal contribution
posted on 2024-06-04, 12:42 authored by Michelle KeskeMichelle Keske, LH Clerk, WJ Price, LA Jahn, EJ Barrett
OBJECTIVE: Ingestion of a mixed meal recruits flow to muscle capillaries and increases total forearm blood flow in healthy young lean people. We examined whether these vascular responses are blunted by obesity. RESEARCH DESIGN AND METHODS: We fed eight middle-aged lean and eight obese overnight-fasted volunteers a liquid mixed meal (480 kcal). Plasma glucose and insulin were measured every 30 min, and brachial artery flow and muscle microvascular recruitment (contrast ultrasound) were assessed every 60 min over 2 h after the meal. RESULTS: By 30 min, plasma glucose rose in both the lean (5.1 +/- 0.1 vs. 6.7 +/- 0.4 mmol/l, P < 0.05) and the obese groups (5.4 +/- 0.2 vs. 6.7 +/- 0.4 mmol/l, P < 0.05). Plasma insulin rose (28 +/- 4 vs. 241 +/- 30 pmol/l, P < 0.05) by 30 min in the lean group and remained elevated for 2 h. The obese group had higher fasting plasma insulin levels (65 +/- 8 pmol/l, P < 0.001) and a greater postmeal area under the insulin-time curve (P < 0.05). Brachial artery flow was increased at 120 min after the meal in the lean group (38 +/- 6 vs. 83 +/- 16 ml/min, P < 0.05) but not in the obese group. Muscle microvascular blood volume rose by 120 min in the lean group (14.4 +/- 2.2 vs. 24.4 +/- 4.2 units, P < 0.05) but not in the obese group. CONCLUSIONS: A mixed meal recruits muscle microvasculature in lean subjects, and this effect is blunted by obesity. This impaired vascular recruitment lessens the endothelial surface available and may thereby impair postprandial glucose disposal.

History

Journal

Diabetes care

Volume

32

Pagination

1672-1677

Location

Arlington, Va.

Open access

  • Yes

ISSN

0149-5992

eISSN

1935-5548

Language

eng

Publication classification

C1.1 Refereed article in a scholarly journal

Copyright notice

2009, American Diabetes Association

Issue

9

Publisher

American Diabetes Association