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On the methods to measure powder flow
journal contribution
posted on 2015-01-01, 00:00 authored by G Tan, David MortonDavid Morton, I Larson© 2015 Bentham Science Publishers. The flow of powders can often play a critical role in the manufacturing of pharmaceutical products. Many of these processes require good, consistent and predictable flow of powders to ensure continuous production of pharmaceutical dosages and to ensure their quality. Therefore, the flow of powders is of paramount importance to the pharmaceutical industry and thus the measuring and evaluating of powder flow is of utmost importance. At present, there are numerous methods in which the flow of powders can be measured. However, due to the complex and environment-dependant nature of powders, no one method exists that is capable of providing a complete picture of the behaviour of powders under dynamic conditions. Some of the most commonly applied methods to measure the flow of powders include: density indices, such as the Carr index and Hausner ratio, powder avalanching, the angle of repose (AOR), flow through an orifice, powder rheometry and shear cell testing.
History
Journal
Current Pharmaceutical DesignVolume
21Issue
40Pagination
5751 - 5765Publisher
Bentham Science PublishersLocation
Schiphol, The NetherlandsPublisher DOI
ISSN
1381-6128eISSN
1873-4286Language
engPublication classification
C1.1 Refereed article in a scholarly journalUsage metrics
Categories
No categories selectedKeywords
Powder flowCarr indexHausner ratiopowder avalancheangle of reposeflow through an orificepowder rheometershear cellScience & TechnologyLife Sciences & BiomedicinePharmacology & PharmacyCAPSULE FILLING PERFORMANCEANNULAR SHEAR CELLWET GRANULATIONEND-POINTPHARMACEUTICAL POWDERSAVALANCHING BEHAVIORSURFACE MODIFICATIONPARTICULATE SOLIDSPARTICLE BREAKAGEIBUPROFEN POWDER