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One-pot synthesis of silicon based nanoparticles with incorporated phthalocyanine for long-term bioimaging and photo-dynamic therapy of tumors
journal contribution
posted on 2017-03-01, 00:00 authored by J Liu, R Wang, S Wu, B Yuan, M Bao, Jingliang LiJingliang Li, Y Dou, Y He, K YangCombining the merits of delivery vectors with drug molecules is one of the key directions for development of efficient cancer monitoring and treatment techniques. In this work, a novel type of silicon based composite nanoparticles (NPs) with incorporated hydrophobic phthalocyanine molecules (Pc) was synthesized via a facile one-pot method. The as-synthesized Pc@Si NPs, with a small size of 4.2 ±0.8 nm, have excellent dispersibility in water and good biocompatibility with cells, in addition to favorable photoluminescence and robust photostability even in cells. Moreover, the Pc@Si NPs show significant in vitro cancer cell killing and in vivo tumor inhibiting abilities upon near-infrared light exposure, due to the photodynamic therapy (PDT) effect of Pc. This work develops an efficient fluorescent PDT drug carrier; moreover, the facile one-pot synthesis strategy may be used generally to prepare silicon-based composite NPs incorporated with diverse hydrophobic drugs/diagnostic molecules for a wide range of biomedical applications.
History
Journal
NanotechnologyVolume
28Issue
13Pagination
2 - 8Publisher
Institute of Physics Publishing LtdLocation
Bristol, United KingdomPublisher DOI
ISSN
0957-4484eISSN
1361-6528Language
engPublication classification
C1 Refereed article in a scholarly journalCopyright notice
2017 IOP PublishingUsage metrics
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No categories selectedKeywords
silicon-based composite nanoparticleone-pot synthesislong-term fluorescence imagingphotodynamic therapyScience & TechnologyTechnologyPhysical SciencesNanoscience & NanotechnologyMaterials Science, MultidisciplinaryPhysics, AppliedScience & Technology - Other TopicsMaterials SciencePhysicsGUIDED CANCER-THERAPYONE-STEP SYNTHESISIN-VIVODRUG-DELIVERYHYDROPHOBIC PHTHALOCYANINEQUANTUM DOTSFLUORESCENTMICELLEPHOTOSENSITIZERS
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