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Optimal H∞ insulin injection control for blood glucose regulation in diabetic patients

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journal contribution
posted on 2005-10-01, 00:00 authored by F Chee, A Savkin, T Fernando, Saeid Nahavandi
The theory of H/sup /spl infin// optimal control has the feature of minimizing the worst-case gain of an unknown disturbance input. When appropriately modified, the theory can be used to design a "switching" controller that can be applied to insulin injection for blood glucose (BG) regulation. The "switching" controller is defined by a collection of basic insulin rates and a rule that switches the insulin rates from one value to another. The rule employed an estimation of BG from noisy measurements, and the subsequent optimization of a performance index that involves the solution of a "jump" Riccati differential equation and a discrete-time dynamic programming equation. With an appropriate patient model, simulation studies have shown that the controller could correct BG deviation using clinically acceptable insulin delivery rates.



IEEE transactions of biomedical engineering




1625 - 1631


Piscataway, N.J.

Open access

  • Yes






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Publication classification

C1 Refereed article in a scholarly journal

Copyright notice

2005, IEEE