Deakin University
Browse
nahavandi-optimalH-2005.pdf (512.83 kB)

Optimal H∞ insulin injection control for blood glucose regulation in diabetic patients

Download (512.83 kB)
journal contribution
posted on 2005-10-01, 00:00 authored by F Chee, A Savkin, T Fernando, Saeid Nahavandi
The theory of H/sup /spl infin// optimal control has the feature of minimizing the worst-case gain of an unknown disturbance input. When appropriately modified, the theory can be used to design a "switching" controller that can be applied to insulin injection for blood glucose (BG) regulation. The "switching" controller is defined by a collection of basic insulin rates and a rule that switches the insulin rates from one value to another. The rule employed an estimation of BG from noisy measurements, and the subsequent optimization of a performance index that involves the solution of a "jump" Riccati differential equation and a discrete-time dynamic programming equation. With an appropriate patient model, simulation studies have shown that the controller could correct BG deviation using clinically acceptable insulin delivery rates.

History

Journal

IEEE transactions of biomedical engineering

Volume

52

Issue

10

Pagination

1625 - 1631

Publisher

IEEE Xplore

Location

Piscataway, N.J.

ISSN

0018-9294

Language

eng

Notes

This material is presented to ensure timely dissemination of scholarly and technical work. Copyright and all rights therein are retained by authors or by other copyright holders. All persons copying this information are expected to adhere to the terms and constraints invoked by each author's copyright. In most cases, these works may not be reposted without the explicit permission of the copyright holder.

Publication classification

C1 Refereed article in a scholarly journal

Copyright notice

2005, IEEE