Optimization and Characterization of the Antimalarial Activity of N-Aryl Acetamides that are Susceptible to Mutations in ROM8 and CSC1

Nguyen, William; Boulet, Coralie; Dans, Madeline G; Loi, Katie; Jarman, Kate E; Barnes, Claudia BG; Yeo, Tomas; Sheth, Tanaya; Mukherjee, Partha; Chakraborty, Arnish; Famodimu, Mufuliat T; Delves, Michael J; Pollard, Harry; Sutherland, Colin J; Coyle, Rachael; Sevilleno, Nicole; Boonyalai, Nonlawat; Lee, Marcus CS; Rabie, Tayla; Birkholtz, Lyn-Marie; Baud, Delphine; Brand, Stephen; Chowdury, Mrittika; De Koning-Ward, Tania; Fidock, David A; Gilson, Paul R; Sleebs, Brad E

Optimization and Characterization of the Antimalarial Activity of N-Aryl Acetamides that are Susceptible to Mutations in ROM8 and CSC1

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posted on 2025-09-19, 15:04 authored by William Nguyen, Coralie Boulet, Madeline G Dans, Katie Loi, Kate E Jarman, Claudia BG Barnes, Tomas Yeo, Tanaya Sheth, Partha Mukherjee, Arnish Chakraborty, Mufuliat T Famodimu, Michael J Delves, Harry Pollard, Colin J Sutherland, Rachael Coyle, Nicole Sevilleno, Nonlawat Boonyalai, Marcus CS Lee, Tayla Rabie, Lyn-Marie Birkholtz, Delphine Baud, Stephen Brand, Mrittika Chowdury, Tania De Koning-WardTania De Koning-Ward, David A Fidock, Paul R Gilson, Brad E Sleebs

Optimization and Characterization of the Antimalarial Activity of N-Aryl Acetamides that are Susceptible to Mutations in ROM8 and CSC1

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DOI - Is version of https://doi.org/10.1021/acs.jmedchem.5c01471

Location

Washington, D.C.

Open access

Yes

Language

eng

Publication classification

C1 Refereed article in a scholarly journal

Journal

Journal of Medicinal Chemistry

Volume

68

Article number

acs.jmedchem.5c01471

Pagination

16613-16644

ISSN

0022-2623

eISSN

1520-4804

Issue

15

Publisher

American Chemical Society

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Keywords

AGENTS BLOOD-STAGE Chemistry, Medicinal DEFINES EGRESS INHIBITORS INVASION Life Sciences & Biomedicine Pharmacology & Pharmacy PLASMODIUM RHOMBOID PROTEASE Science & Technology

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CC BY-NC-ND 4.0

Optimization and Characterization of the Antimalarial Activity of N-Aryl Acetamides that are Susceptible to Mutations in ROM8 and CSC1

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