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Orbitofrontal sulcogyral patterns are related to temperamental risk for psychopathology

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journal contribution
posted on 01.02.2014, 00:00 authored by S Whittle, C Bartholomeusz, M Yücel, M Dennison, Nandi VijayakumarNandi Vijayakumar, N B Allen
There are marked individual differences in the pattern of cortical (sulcogyral) folding in the orbitofrontal cortex (OFC), and there is a growing literature suggesting that these individual differences are associated with risk for psychotic disorders. To date, however, no study has investigated whether OFC folding patterns are associated with broader risk factors relevant to a range of psychopathology. This study helps address this knowledge gap by examining whether OFC sulcogyral folding patterns are associated with putative risk factors, specifically affective temperament and psychiatric symptoms, in a large community sample (N = 152) of adolescents. Results showed that the most common pattern of folding ('Type I', marked by discontinuity of the medial orbital sulcus and continuity of the lateral orbital sulcus) was associated with low levels of Surgency, high levels of Negative Affectivity (in girls) and higher depressive symptoms. This pattern was also associated with reduced thickness of OFC gray matter. Overall, the findings, combined with previous work, suggest some specificity of neurodevelopmental risk for different types of psychopathology. Thus, these results have the potential to inform the early identification of at-risk individuals. © The Author (2012).

History

Journal

Social cognitive and affective neuroscience

Volume

9

Issue

2

Pagination

232 - 239

Publisher

Oxford University Press

Location

Oxford, Eng.

ISSN

1749-5024

eISSN

1749-5024

Language

eng

Publication classification

C1 Refereed article in a scholarly journal

Copyright notice

2012, The Authors