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Origins of fetal growth restriction
journal contribution
posted on 2000-09-01, 00:00 authored by J S Robinson, V M Moore, Julie OwensJulie Owens, I C McMillenRegulation of growth of the fetus and its placenta begins before pregnancy. Early in pregnancy the mother sets the rate of growth of the fetus on a trajectory, which may be modified by events later in pregnancy. Low maternal weight for height, history of previous small babies, maternal undernutrition, pregnancy disorders, e.g. pre-eclampsia, are associated with low birthweight. Maternal smoking is a major factor in developed countries; infections and undernutrition in developing countries.Recently, there has been emphasis on adverse long-term outcomes including ischaemic heart disease, hypertension and diabetes associated with poor fetal growth. Experimental studies in animals show that some of these outcomes can readily be induced by restriction of fetal growth. Progress in determining successful treatments to improve the growth of the fetus has lagged behind these epidemiological and experimental findings. However, nutrient supplements improve growth in undernourished women and smoking cessation also improves fetal size and outcome.
History
Journal
European journal of obstetrics & gynecology and reproductive biologyVolume
92Issue
1Pagination
13 - 19Publisher
ElsevierLocation
Amsterdam, The NetherlandsPublisher DOI
ISSN
0301-2115Language
engPublication classification
C1.1 Refereed article in a scholarly journalCopyright notice
2000, Elsevier Science Ireland Ltd.Usage metrics
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No categories selectedKeywords
AnimalsBirth WeightEmbryonic and Fetal DevelopmentFemaleFetal Growth RetardationHumansInfant, NewbornMaleNutritional Physiological PhenomenaParityPedigreePregnancyPregnancy ComplicationsPregnancy, MultipleRatsSmokingScience & TechnologyLife Sciences & BiomedicineObstetrics & GynecologyReproductive Biologycausesfetal growth restrictionlong-term outcomesnutrient supplementsLOW-BIRTH-WEIGHTRANDOMIZED CONTROLLED TRIALFUNDAL HEIGHT-MEASUREMENTPREGNANT-WOMENMATERNAL NUTRITIONGUINEA-PIGSOUTH-WESTFACTOR-IPOPULATIONRETARDATION
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