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Outcomes of endovascular thrombectomy with and without bridging thrombolysis for acute large vessel occlusion ischaemic stroke

Version 2 2024-06-05, 02:55
Version 1 2018-09-10, 14:14
journal contribution
posted on 2024-06-05, 02:55 authored by Julian MaingardJulian Maingard, Yasmin Shvarts, Ronan Motyer, Vincent Thijs, Paul Brennan, Alan O'Hare, Seamus Looby, John Thornton, Joshua A Hirsch, Christen D Barras, Ronil V Chandra, Mark Brooks, Hamed AsadiHamed Asadi, Hong Kuan Kok
INTRODUCTION: Endovascular thrombectomy (EVT) for management of large vessel occlusion (LVO) acute ischaemic stroke (AIS) is now current best practice. The aim of this study was to determine if bridging intravenous alteplase therapy confers any clinical benefit. METHODS: A retrospective study of patients treated with EVT for LVO was performed. Outcomes were compared between patients receiving thrombolysis and EVT with EVT alone. Primary endpoints were reperfusion rate, 90-day functional outcome and mortality using the modified Rankin scale (mRS) and symptomatic intracranial haemorrhage (sICH). RESULTS: A total of 355 patients who underwent EVT were included: 210 with thrombolysis (59%) and 145 without (41%). The reperfusion rate was higher in the group receiving IV tPA (unadjusted OR 2.2, 95% CI: 1.29-3.73, p=0.004) although this effect was attenuated when all variables were considered (adjusted OR [AOR] 1.22, 95% CI: 0.60-2.5, p=0.580). The percentage achieving functional independence (mRS 0-2) at 90-days was higher in patients who received bridging IV tPA (AOR 2.17, 95% CI:1.06-4.44, p=0.033). There was no significant difference in major complications including sICH (AOR 1.4, 95% CI: 0.51-3.83, p=0.512). There was lower 90-day mortality in the bridging IV tPA group (AOR 0.79, 95% CI: 0.36-1.74, p=0.551). Fewer thrombectomy passes (2 versus 3, p=0.012) were required to achieve successful reperfusion in the IV tPA group. Successful reperfusion (mTICI ≥2b) was the strongest predictor for 90-day functional independence (AOR 10.4, 95% CI:3.6-29.7, p<0.001). CONCLUSIONS: Our study supports the current practice of administering intravenous alteplase before endovascular therapy.



Internal medicine journal






Chichester, Eng.





Publication classification

C1 Refereed article in a scholarly journal

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2018, Royal Australasian College of Physicians




John Wiley & Sons